Publications

2017

Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, Rickert RC. Gsk3 is a metabolic checkpoint regulator in B cells. Nat Immunol. 2017 Mar;18(3):303-312. doi: 10.1038/ni.3664.

Ramezani-Rad P, Rickert RC. Murine models of germinal center derived-lymphomas. Curr Opin Immunol. 2017 Feb 1;45:31-36. doi: 10.1016/j.coi.2016.12.002.

Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, Rickert RC. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017 Feb 1;198(3):1066-1080. doi: 10.4049/jimmunol.1502518.

2016

Miletic AV, Jellusova J, Cato MH, Lee CR, Baracho GV, Conway EM, Rickert RC. 2016. Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells. J Immunol. 196(5):2195-204. doi: 10.4049/jimmunol.1501690.

Jellusova and RC Rickert. 2016. TNF and TNFR Family Members and B Cell Activation. Encyclopedia of Immunobiology. M. Ratcliffe (ed.). Elsevier (Pub.).

Jellusova J, Rickert RC. 2016. The PI3K pathway in B cell metabolism. Crit Rev Biochem Mol Biol. 1-20. Epub ahead of print

2015

Jin HY, Gonzalez-Martin A, Miletic AV, Lai M, Knight S, Sabouri-Ghomi M, Head SR, Macauley MS, Rickert RC, Xiao C. 2015. Transfection of microRNA Mimics Should Be Used with Caution. Front Genet. 6:340. doi: 10.3389/fgene.2015.00340. eCollection 2015

Rickert R. 2015. DUSP4 phosphatase puts the brakes on DLBCL. J Exp Med. 212(5):598-9. doi: 10.1084/jem.2125insight2.

Ardecky R, Sergienko E, Zou J, Ganji S, Brown B, Sun Q, Ma CT, Hood B, Nguyen K, Vasile S, Suyama E, Mangravita-Novo A, Salaniwal S, Kung P, Smith LH, Chung TDY, Jackson MR, Pinkerton AB, Rickert R. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2014. Updated 2015 Jan 16.

2014

Almaden JV, Tsui R, Liu YC, Birnbaum H, Shokhirev MN, Ngo KA, Davis-Turak JC, Otero D, Basak S, Rickert RC, Hoffmann A. 2014. A pathway switch directs BAFF signaling to distinct NFκB transcription factors in maturing and proliferating B cells. Cell Rep. 9(6):2098-111. doi: 10.1016/j.celrep.2014.11.024.

Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA. 2014. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 33(34):4330-9. doi: 10.1038/onc.2013.383

Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, Müller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA. 2014. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. J Immunol. 193(2):909-20.

Baracho GV, Cato MH, Zhu Z, Jaren OR, Hobeika E, Reth M, Rickert RC. 2014. PDK1 regulates B cell differentiation and homeostasis. Proc Natl Acad Sci U S A. 111(26):9573-8.

2013

Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA. 2013. The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Hum Immunol. 74(5):574-85.

Yau IW, Cato MH, Jellusova J, Hurtado de Mendoza T, Brink R, Rickert RC. 2013. Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol. 191(3):1082-90.

Rickert RC. 2013. New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol. 13(8):578-91.

Lee K, Heffington L, Jellusova J, Nam KT, Raybuck A, Cho SH, Thomas JW, Rickert RC, Boothby M. 2013. Requirement for Rictor in homeostasis and function of mature B lymphoid cells. Blood. 122(14):2369-79.

Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC. 2013. Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep. 5(4):1022-35.

2012

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L. 2012. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 8(5):437-46.

Rickert RC, Salvesen GS, Ware CF. 2012. Mousing around with caspases and IAPs. Biochem J. 443(2):e1-2.

Johnson K, Chaumeil J, Micsinai M, Wang JM, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA. 2012. IL-7 Functionally Segregates the Pro-B Cell Stage by Regulating Transcription of Recombination Mediators across Cell Cycle. J Immunol. 188(12):6084-92.

Powers SE, Mandal M, Matsuda S, Miletic AV, Cato MH, Tanaka A, Rickert RC, Koyasu S, Clark MR. 2012. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J Exp Med. 209(12):2199-213.

2011

Baracho, G.V., A.V. Miletic, S.A. Omori, M.H. Cato and R.C. Rickert. 2011. Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Curr. Opin. Immunol. 23(2):178-83.

Cato, M.H., I.W. Yau and R.C. Rickert. 2011. Magnetic-based purification of “untouched” murine germinal center B cells for ex- vivo manipulation and biochemical analysis. Nat. Protocols. 9;6(7):953-60.

R.C. Rickert, J. Jellusova and A.V. Miletic. 2011. Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease. Immunol. Rev. 44(1):115-33.

2010

Browne, C.D., M.M. Hoefer, S.K. Chintalapati, M.H. Cato, Y. Wallez, E.B. Pasquale and R.C. Rickert. 2010. SHEP1 partners with CasL to promote marginal zone B cell maturation. Proc. Natl. Acad. Sci. USA.;107(44):18944-9

Miletic A.V., A.N. Anzelon-Mills, D.M. Mills, S.A. Omori, I.M. Pedersen, J.V. Ravetch, S. Bolland, H. C. Morse III and R.C. Rickert. 2010. Coordinate suppression of B cell lymphoma by PTEN and SHIP. J. Exp. Med. 207(11):2407-20.

Li S, Ezhevsky S, Dewing A, Cato MH, Scortegagna M, Bhoumik A, Breitwieser W, Braddock D, Eroshkin A, Qi J, Chen M, Kim JY, Jones S, Jones N, Rickert R, Ronai ZA. 2010 Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice. Genes Cancer. 1(4):316-330.

Cato MH, Chintalapati SK, Yau IW, Omori SA, Rickert RC. Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol. Cell Biol. 31(1):127-37.

Vang T., Y. Xie, W.H. Liu, D. Vidović, Liu Y, S. Wu, D.H. Smith, A. Rinderspacher, C. Chung, G. Gong, T. Mustelin, D.W. Landry, R.C. Rickert, S.C. Schürer, S.X. Deng and L. Tautz. 2010. Inhibition of Lymphoid Tyrosine Phosphatase by Benzofuran Salicylic Acids. J. Med. Chem. 54(2):562-571.

2009

Browne, C.D., C.J. Del Nagro, M.H. Cato, S.H. Dengler and R.C. Rickert. 2009. Suppression of PI(3,4,5)P3 production is a key determinant of B cell anergy. Immunity. 5(31):749-60

Cantor, J., C.D. Browne, R. Ruppert, C. Feral, Reinhard Fässler, R.C. Rickert* and M. Ginsberg. 2009. CD98hc enables B cell clonal expansion and adaptive humoral immunity. Nat. Immunol. 10(4):412-9 *co-corresponding author.

Pedersen, I.M., D. Otero, E. Kao, A.V Miletic, C. Hother, E. Ralfkiaer, R.C. Rickert, K. Gronbaek and Michael David. 2009. Onco-miR-155 targets SHIP1 to promote TNFa-dependent growth of B cell lymphomas. EMBO Mol. Med.(5):288-95.

Wu, S., Bottini, M., Rickert, R.C., Mustelin, T., Tautz, L. 2009. In Silico Screening for PTPN22 Inhibitors: Active Hits From an Inactive Phosphatase Conformation. ChemMedChem. 4(3):440 4.

2008

Brunsing, R., Omori-Fitzpatrick, S., Weber, F., Ware, A., Friend, L., Rickert, R.C., and Niwa, M. 2008. B- and T-cell Development Both Involve Activity of the Unfolded Protein Response Pathway. J. Biol. Chem. 283(26):17954-61.

Cato MH, F. D’Annibale, D.M. Mills, F. Cerignoli, M.I. Dawson, E. Bergamaschi, N. Bottini, A. Magrini, A., Bergamaschi A, N. Rosato, R.C. Rickert, T. Mustelin, and M. Bottini. 2008. Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. J. Nanosci. Nanotechnol. 8(5):2259-69.

Dengler, S.H., G.V. Baracho, S.A. Omori, S. Bruckner, K.C. Arden, D.H. Castrillon, R.A. Depinho and R.C. Rickert. 2008. Distinct roles for Foxo1 at multiple stages of B cell differentiation. Nat. Immunol. 12:1388-98.

2007

Kolla, R.K., S. Chintalapati, M. Sabet, E. Santelli, R. Liddington, M. David, J. Fierer, D. Guiney and R.C. Rickert. Complement C3d conjugation to Anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS ONE.

Vang, T., A.V. Miletic, Y. Arimura, L. Tautz, R.C. Rickert and T. Mustelin. 2007. Protein Tyrosine Phosphatases in Autoimmunity. Ann. Rev. of Immunol.

Omori, SA, and Rickert, RC. 2007. Phosphatidylinositol 3-kinase (PI3K) Signaling and Regulation of the Antibody Response. Cell Cycle. 6(4):397-402

Mills, DM, Bonizzi, G., Karin M., and Rickert, RC. 2007. Regulation of late B cell differentiation by intrinsic IKKa-dependent signals. Proc. Natl. Acad. Sci. U S A. 104(15):6359-6364.

2006

Fornek, J.L., Tygrett, L.T., Waldschmidt, T.J., Poli, V., Rickert, R.C., and Kansas, G.S.. 2006. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood. 107(3):1085-91.

Enzler, T., G. Bonizzi, G.J. Silverman, A.N. Anzelon-Mills, D.C. Otero, G.F. Widhopf, R.C. Rickert and M. Karin. 2006. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 25:403-415.

Omori, S.A., M.H. Cato, A.N. Anzelon-Mills, K.D. Puri, M. Shapiro-Shelef, K. Calame and R.C. Rickert. 2006. Regulation of Class Switch Recombination and Plasma Cell Differentiation by the PI3K/Akt/Foxo Signaling Axis. Immunity. 25:545-557. (Highlighted in Science’s STKE, 2006, tw365)

Otero, D.C., V. Poli, M. David and R.C. Rickert. 2006. Inherent and acquired resistance to radiation-induced apoptosis in B cells: A pivotal role for STAT3. J. Immunol: Cutting Edge. 177:6593-6597.

2005

Del Nagro, C.J., D.C. Otero, A.N. Anzelon, S.A. Omori, R.V. Kolla and R.,C. Rickert. 2005. CD19 function in central and peripheral B cell development. Immunol. Res. 39:119-132.

Rickert, R.C. 2005. Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex. Current Opin. Immunol. 17:237-243.

Del Nagro, C.J., Kolla, R.V. and R.C. Rickert. 2005. A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis. J. Immunol. 175:5379-5389.

2004

Li, Z-W., R. C. Rickert and M. Karin. 2004. Genetic dissection of antigen receptor induced-NF-kB activation. Mol. Immunol. 41:701-14.

Bonizzi, G., M. Bebien, D. C. Otero, K. E. Johnson-Vroom, Y. Cao, D. Vu, A. Jegga, B. Aronow, V. G. Ghosh, R. C. Rickert and M. Karin. 2004. Selective activation of IKKa target genes depends on induction of RelB:p52 dimers that recognize special kB binding sites. EMBO. 23:4202–4210.

Qian, Y., J. Qin, S.A. Omori, M. Naramura, E.C. Snow, C.F. Ware, R.L. Fairchild, R. C. Rickert, B.L. Kotzin and X. Li. 2004. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 21:575-587.

2003

Goda, N., H. E. Ryan, B. Khadivi, W. McNulty, R.C. Rickert, and R.S. Johnson. 2003. HIF-1a is essential for cell cycle arrest during hypoxia. Mol. Cell. Biol. 23:359-69.

Otero, D.C., A.N. Anzelon and R.C. Rickert. 2003. CD19 function in early and late B cell development: I. Maintenance of follicular and marginal zone B Cells requires CD19-dependent survival signals. J. Immunol. 170:73-83.

Anzelon, A.N., H. Wu and R.C. Rickert. 2003. Pten inactivation alters B lymphocyte fate and reconstitutes CD19 function. Nature Immunol. 4:287-294.

Li, Z-W., S. A. Omori, T. Labuda, M. Karin and R. C. Rickert. 2003. IKKb is required for peripheral B cell proliferation and survival. J. Immunol. 170:4630-4637.

Otero, D.C. and R.C. Rickert. 2003. CD19 function in early and late B cell development: II. Progression through the pro-B/pre-B cell transition is facilitated by CD19. J. Immunol. 171:5921-5930.

2002

Wang, Y., S. Brooks, X. Li, A.N. Anzelon, R.C. Rickert and R.H. Carter. 2002. The physiologic role of CD19 cytoplasmic tyrosines. Immunity 17:501-514.

2001

Otero, D. C., S. A. Omori and R. C. Rickert. 2001. CD19-dependent activation of Akt kinase in B lymphocytes. J Biol Chem. 276:1474-1478.

Moreno de Alboran, I., R. C. O’Hagan, F. Gärtner, B. Malynn, L. Davidson, R. C. Rickert, K. Rajewsky, R. A. DePinho and F. W. Alt. 2001. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity 14:45-55.

2000

Omori, S. A., D. Otero and R. C. Rickert. 2000. B cell coreceptor function: The CD19 connection. In: Antibodies. (Capra, D. and Zanetti, M., eds). Harwood Academic Publishers. 6:151-201.

Buhl, A. M., D. Nemazee, J. C. Cambier, R. C. Rickert and M. Hertz. 2000. B-cell antigen receptor competence regulates B lymphocyte selection and survival. Immunol Rev.176:141-53.

1999

Su, L. L., R. C. Rickert and M. David. 1999. Rapid STAT phosphorylation via the B cell receptor: Modulatory role of CD19. J Biol Chem. 274:31770-31774.

1998

Fehr, T., R. C. Rickert, B. Odermatt, J. Roes, K. Rajewsky, H. Hengartner and R. M. Zinkernagel. 1998. Antiviral protection and germinal center formation, but impaired B-cell memory in the absence of CD19. J. Exp. Med. 188:145-155.

1997

Rickert, R. C., J. Roes and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25:1317-1318.

Buhl, A. M., C. M. Pleiman, R. C. Rickert and J. C. Cambier. 1997. Qualitative regulation of B-cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-triphosphate production and Ca++ mobilization. J. Exp. Med. 186:1897-1910.

1996

Rickert. R.C. 1996. Control points and affinity maturation in antibody formation, Handbook of Experimental Immunology. 5th edition, (ed. L. Herzenberg). Blackwell Publishing.

1995

Rickert, R. C., M.K. Wloch, R. Hahn and S. Clarke. 1995. Binding analysis of antibodies produced by precursor and branchpoint intermediates of an anti-influenza hemagglutinin B cell clone: parallel replacement mutations do not confer increased avidity for hemagglutinin. J. Immunol. 154:2209-2216.

Rickert, R. C., K. Rajewsky and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352-355.

1994

Christoph, T., R. C. Rickert and K. Rajewsky. 1994. M17: a novel gene expressed in germinal centers. Int. Immunol.6:1203-1211.

1993

Rickert, R., and S. Clarke. 1993. Low frequency of somatic mutation in two expressed Vk genes: unequal distribution of mutation in 5′ and 3′ flanking regions. Int. Immunol. 5:255-263.

1990

Clarke, S., R. C. Rickert, M.K. Wloch, L. Staudt, W. Gerhard, and M. Weigert. 1990. The BALB/c secondary response to the Sb site of influenza virus hemagglutinin: nonrandom silent mutation and unequal numbers of VH and Vk mutations. J. Immunol. 145:2286-2296.